DTSF/HB-EGF polyclonal antibody, Unconjugated, Rabbit

Produktübersicht

• Artikelname: DTSF/HB-EGF polyclonal antibody, Unconjugated, Rabbit
• Artikelnummer: BWT-BS65575
• Hersteller Artikelnummer: BS65575
• Alternativnummer: BWT-BS65575-50UL,BWT-BS65575-100UL
• Hersteller: Bioworld Technology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IHC-P
• Spezies Reaktivität: Bovine, Human, Mouse, Porcine, Rat, Sheep
• Immunogen: KLH conjugated synthetic peptide derived from human DTSF/HB-EGF:20-62/208
• Konjugation: Unconjugated
• Alternative Synonym: HB EGF, Diphtheria toxin receptor, DT R, DT-R, DTR, DTS, DTSF, HB-EGF, HBEGF, HBEGF_HUMAN, HEGFL, heparin binding EGF like growth factor, Heparin binding epidermal growth factor, Heparin binding epidermal growth factor like growth factor, Heparin-binding EGF-like growth factor, Proheparin binding EGF like growth factor.

Produktbeschreibung

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a 22kDa O-glycosylated protein that is a potent mitogen and chemoattractant for vascular smooth muscle cells, fibroblasts and epithelial cells but not endothelial cells. The natural protein has an apparent molecular mass of 19-23 kDa and exists in multiple forms as a result of heterogeneous O-glycosylation and/or Nterminal truncation. HB-EGF is synthesized as a membrane-anchored precursor(proHB-EGF) that is proteolytically cleaved to release the soluble mature growth factor. The two forms are active as juxtacrine and paracrine/autocrine growth factors respectively.HB-EGF activates two EGF receptor subtypes, HER1/ErbB1 and HER4 and binds to heparan sulfate proteoglycan.

Produkteigenschaften

• Molekulargewicht: ~21kDa
• UniProt: Q99075
• Reinheit: affinity purified by Protein A
• Formulierung: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Anwendungsbeschreibung

• Application Verdünnung: IHC-P=1:100-500() not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
• Anwendungsbeschreibung: DTSF/HB-EGF polyclonal Antibody detects endogenous levels of DTSF/HB-EGF protein.