Bovine, Canine, Equine, Human, Mouse, Porcine, Rabbit, Rat
Immunogen:
KLH conjugated Synthesised phosphopeptide derived from human p53BP1 around the phosphorylation site of Ser25/29:ED(p-S)QPE(p-S)QV
Konjugation:
Unconjugated
Alternative Synonym:
53BP1 (phospho S25), p-53BP1 (phospho S25) ,53BP1 (Phospho-Ser25/29), 53BP1 (Phospho-S25/S29), phospho-p53BP1(Ser25/Ser29), P-53BP1 (Ser25/29), 53 BP1, FLJ41424, MGC138366, p202, p53 binding protein 1, p53 BP1, p53BP1, TP53 BP1, TP53BP1, Tumor protein 53 binding protein 1, Tumor protein p53 binding protein 1, Tumor suppressor p53 binding protein 1, TP53B_HUMAN, tumor protein 53-binding protein, 1.
p53 binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double strand breaks. This also suggests a role in DNA repair, maintaining genomic stability.
