Bovine, Canine, Human, Mouse, Porcine, Rabbit, Rat, Sheep
Immunogen:
KLH conjugated Synthesised phosphopeptide derived from human PIM1 around the phosphorylation site of Tyr309
Konjugation:
Unconjugated
Alternative Synonym:
PIM1 (phospho Y309), PIM1 (phospho Tyr309), Oncogene PIM 1, Oncogene PIM1, PIM 1, Pim 1 kinase, Pim 1 oncogene, PIM, Pim2, PIM3, Proto oncogene serine/threonine protein kinase Pim 1, Proviral integration site 1, Proviral integration site 2
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011].
