Bovine, Canine, Equine, Human, Mouse, Porcine, Rabbit, Rat
Immunogen:
KLH conjugated synthetic peptide derived from human MAPK organizer 1:201-315/315
Konjugation:
Unconjugated
Alternative Synonym:
MAPK organizer 1, MGC4238, Mitogen activated protein kinase organizer 1, Mitogen-activated protein kinase organizer 1, MORG 1, WD repeat domain-containing protein 83, wdr83, WDR83_HUMAN.
This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants.
