KLH conjugated synthetic peptide derived from human CARD4:51-150/953
Konjugation:
Unconjugated
Alternative Synonym:
CARD 4, CARD4, Caspase recruitment domain 4, Caspase recruitment domain containing protein 4, Caspase recruitment domain family member 4, Caspase recruitment domain protein 4, Caspase recruitment domain-containing protein 4, CLR 7.1, CLR7.1, NLR family CARD domain containing 1, NLRC 1, NLRC1, NOD 1, Nod1, NOD1 protein, NOD1_HUMAN, Nucleotide binding oligomerization domain containing 1, Nucleotide binding oligomerization domain leucine rich repeat and CARD domain containing 1, Nucleotide-binding oligomerization domain-containing protein 1, Protein Nod1.
Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB.
