Bovine, Canine, Equine, Human, Mouse, Porcine, Rabbit, Rat, Sheep
Immunogen:
KLH conjugated synthetic peptide derived from human SMC6:155-260/1091
Konjugation:
Unconjugated
Alternative Synonym:
SMC6L1, SMC 6, SMC6, SMC6 protein, SMC6 structural maintenance of chromosomes 6 like 1, Structural maintenance of chromosomes 6, Structural maintenance of chromosomes 6 like 1, Structural maintenance of chromosomes protein 6.
SMC5/6 complex is recruited to nuclease induced double strand breaks (DSBs) and is required for the recruitment of cohesin to DSBs. The human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage induced apoptosis by facilitating DNA repair in human cells.