Recombinant fusion protein of human CPEB3(NP_055727.3).
Konjugation:
Unconjugated
Alternative Synonym:
CPEB3
Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE, a uridine-rich sequence element within the mRNA 3-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity. Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity. In the basal state, binds to the mRNA 3-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity. Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity. When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
