A synthetic phosphorylated peptide around S795 of human RB(NP_000312.2).
Konjugation:
Unconjugated
Alternative Synonym:
OSRC,PPP1R130,RB,p105-Rb,pRb,pp110,RB1,Rb
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB,1:500 - 1:2000|IHC,1:50 - 1:200
Anwendungsbeschreibung:
Phosphorylated
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