Anti elastase, EI, ELANH2, ILEU_HUMAN, LEI, Leukocyte elastase inhibitor, M/NEI, MNEI, Monocyte/neutrophil elastase inhibitor, Peptidase inhibitor 2, Pi-2, PI2, Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 1, Serpin B1, Serpin peptidase inhibitor clade B (ovalbumin) member 1, serpinb1,
The serine proteinase inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. The monocyte/neutrophil elastase inhibitor gene, SERPINB1, belongs to the Ov-serpin family (ovalbumin-related serpins). Human SerpinB1, also designated monocyte/neutrophil elastase inhibitor (M/NEI) or leukocyte elastase inhibitor (LEI), is a cytoplasmic protein which acts as a fast-acting stoichiometric proteinase inhibitor that regulates the activity of neutrophil elastase (NE), cathepsin-G and proteinase-3. There are four homologous genes in mouse designated SerpinB1a, SerpinB1b, SerpinB1c and the pseudogene, Serpinb1-ps1. The three protein-coding genes share significant sequence identity, however SerpinB1a (also designated EIA) has been characterized as the functional ortholog of human SerpinB1.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB: 1:500~1:2000 IF: 1:50~1:200
Anwendungsbeschreibung:
SERPINB1 polyclonal antibody detects endogenous levels of SERPINB1 protein.
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