Enables K63-linked polyubiquitin modification-dependent protein binding activity, identical protein binding activity, and ionotropic glutamate receptor binding activity. Involved in several processes, including brown fat cell proliferation, energy homeostasis, and positive regulation of long-term synaptic potentiation. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in several cellular components, including aggresome, autolysosome, and sperm midpiece. Is expressed in several structures, including alimentary system, central nervous system, genitourinary system, limb, and sensory organ. Used to study Pagets disease of bone. Human ortholog(s) of this gene implicated in GNE myopathy, Pagets disease of bone, and frontotemporal dementia and/or amyotrophic lateral sclerosis-3. Orthologous to human SQSTM1 (sequestosome 1).
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB,1:500 - 1:2000
Anwendungsbeschreibung:
Unmodification
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