NPT2, SLC17A2, Sodium-dependent phosphate transport protein 2A, Sodium-phosphate transport protein 2A, Na(+)-dependent phosphate cotransporter 2A, NaPi-3, Sodium/phosphate cotransporter 2A, Na(+)/Pi cotransporter 2A, NaPi-2a, Solute carrier family 34 member 1
Renal tubular reabsorption of phosphate is critical to the maintenance of phosphate homeostasis in mammals. The brush-border membrane Na+/Pi cotransport systems in proximal tubules play a major role in this process. The renal Na(+)/P(i) cotransporter NPT2 is expressed in the brush border membrane (BBM) of proximal tubular cells . NPT2 gene expression is crucial for PTH effects on renal P(i) handling. However, renal expression of the sodium/phosphate cotransporter gene, NPT2, is not required for regulation of renal 1 alpha-hydroxylase by phosphate. NPT2 is an integral membrane protein expressed in kidney and lung. The gene encoding human NPT1 maps to chromosome 6q21.3-p23, while the gene encoding human NPT2 maps to chromosome 5q35.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200
Anwendungsbeschreibung:
SLC34A1 polyclonal antibody detects endogenous levels of SLC34A1 protein.
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