Nuclear inhibitor of protein phosphatase 1, NIPP-1, Protein phosphatase 1 regulatory inhibitor subunit 8, Activator of RNA decay, ARD-1, PPP1R8, ARD1
NIPP1 (nuclear inhibitor of protein phosphatase 1) is a putative transcription regulator that may be involved in pre-mRNA splicing and cell proliferation. NIPP1 contains a nuclear signaling region named FHA (fork-head associated) domain. The FHA domain has been associated with protein kinases and transcription factors. The NIPP1 locus encodes for three different isoforms termed alpha, beta and gamma due to alternative splicing events. The isoforms exhibit RNA binding activity and also act as phophatase inhibitors. The gamma isoform is believed to be a magnesium dependent endoribonuclease that is responsible for cleaving RNA strands. It is mainly found in B cells and T lymphocytes. The alpha and beta isoforms are localized in the brain and kidney. Inactivation of NIPP1 is accomplished by the phosphorylation of Ser 199 or Ser 204. NIPP1 interacts with proteins CDc5L, SAP 155, MELK and EED.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB: 1:500~1:2000 IHC/IF: 1:50~1:200
Anwendungsbeschreibung:
NIPP1 polyclonal antibody detects endogenous levels of NIPP1 protein.
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