Full length human recombinant protein of human SDCBP(NP_005616) produced in HEK293T cell.
Konjugation:
Unconjugated
Alternative Synonym:
Syntenin-1, Melanoma differentiation-associated protein 9 (MDA-9), Pro-TGF-alpha cytoplasmic domain-interacting protein 18 (TACIP18), Scaffold protein Pbp1, Syndecan-binding protein 1, SDCBP
Syntenin-1 (MDA9, SDCBP) is a member of the PDZ family of proteins, defined by the presence of a PDZ protein interaction domain. Syntenin-1, via its PDZ domain, functions as a scaffold adaptor protein that regulates numerous signal transduction pathways, including FAK, Src, TGFbetaR1, EGFR, and IGF1R. Aberrantly elevated expression of syntenin-1 has been found in various cancers, and has been linked to growth and invasion of tumor cells. In the central nervous system, syntenin-1 has been shown to mediate neuron dendrite protrusion and spine formation through its interaction with syndecan and Rheb. Syntenin-1 is also a key component of the syndecan/syntenin/ALIX pathway which has been shown to directly contribute to the formation and internalization of exosomes.
The antibody was affinity-purified from mouse ascites fluids or tissue culture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Verdünnung:
WB 1:500~2000, IHC 1:150
Anwendungsbeschreibung:
IgG1
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