Antigen receptors found on the surface of B cells contain a heterodimeric signaling component composed of CD79A and CD79B, also known as Ig alpha and Ig beta, respectively . Presence of this receptor complex is essential for B cell development and function. Together these two proteins and the associated B cell receptor (BCR) initiate intracellular signaling following antigen binding . An immunoreceptor tyrosine-based activation motif (ITAM) found in the CD79A intracellular region appears to be important for its function . Antigen binding precedes formation of the CD79A and CD79B heterodimer and subsequent activation of receptor associated kinases . Research has shown that CD79A is a marker for B-lineage lymphoblastic leukemia . Additionally, investigators have found that mutations in the CD79A (MB1) gene are associated with abnormally low levels of functional B cell receptors in some cases of chronic B cell lymphocytic leukemia .
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Formulierung:
Mouse IgG2b. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
Application Verdünnung:
IHC (1/100 - 1/300)
Anwendungsbeschreibung:
Recognizes endogenous levels of CD79a protein.
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