Caspase 8 monoclonal antibody, Unconjugated, Mouse

Produktübersicht

• Artikelname: Caspase 8 monoclonal antibody, Unconjugated, Mouse
• Artikelnummer: BWT-MB67106
• Hersteller Artikelnummer: MB67106
• Alternativnummer: BWT-MB67106-50UL,BWT-MB67106-100UL
• Hersteller: Bioworld Technology
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: FC, WB
• Spezies Reaktivität: Human
• Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Caspase 8. The exact sequence is proprietary.
• Konjugation: Unconjugated
• Alternative Synonym: MCH5, Caspase-8, CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, MACH

Produktbeschreibung

Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10. Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.

Produkteigenschaften

• Molekulargewicht: ~ 57 kDa
• UniProt: Q14790
• Reinheit: This antibody is purified through a protein G column.
• Formulierung: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Anwendungsbeschreibung

• Application Verdünnung: WB (1/500 - 1/1000), FC (1/10 - 1/50)
• Anwendungsbeschreibung: Recognizes endogenous levels of Caspase 8 protein.