Recombinant fusion protein of human XRN1. The exact sequence is proprietary.
Konjugation:
Unconjugated
Alternative Synonym:
SEP1, 5-3 exoribonuclease 1, Strand-exchange protein 1 homolog
5-3 exoribonuclease 1 (XRN1) is a cytoplasmic exonuclease that degrades RNA containing a 5-monophosphate to component mononucleotides. XRN1 is the primary exonuclease associated with ribosomes in the cytoplasm and is responsible for mRNA turnover. This turnover is facilitated in discrete structures in the cytoplasm called P-bodies that contain decapping and deadenylation proteins. XRN1 also plays a role in RISC-mediated mRNA degradation, as it associates with 3 mRNA fragments generated by RISC cleavage. This process does not require uncapping or deadenylation. XRN1 plays a significant role in viral RNA degradation. As such, many viral genomes, including hepatitis C, Dengue, and West Nile, encode for XRN1-resistant long non-coding RNA that affect innate immunity and viral replication.
