Recombinant fusion protein of human PURB. The exact sequence is proprietary.
Konjugation:
Unconjugated
Alternative Synonym:
Transcriptional activator protein Pur-beta, Purine-rich element-binding protein B
Purbeta (purine-rich element-binding protein B), also known as transcriptional activator protein Purbeta, is a 312 amino acid protein that belongs to the PUR DNA-binding protein family. The Purbeta gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, the Purbeta protein is implicated in the control of both DNA replication and transcription. Deletion of the Purbeta gene has been asso ciated with myelodysplastic syndrome and acute myelogenous leukemia (AML), which is a malignant disease where in hematopoietic precursors are arrested in an early stage of development. Localizing to nucleus, the Purbeta protein is expressed in myocardium of heart failure patients. The Purbeta gene is conserved in mouse, rat, zebrafish, fruit fly, mosquito, C. elegans, A. thaliana and rice. and maps to human chromosome 7p13.
