Recombinant fusion protein of human CARD9. The exact sequence is proprietary.
Konjugation:
Unconjugated
Alternative Synonym:
Caspase recruitment domain-containing protein 9, hCARD9
CARD9 is a caspase recruitment domain (CARD)-containing adaptor protein expressed by myeloid cells. It is required for antifungal immunity downstream of pathogen detection by C-type lectin receptors (CLRs) such as Dectin-1. Recognition of carbohydrates on fungal cell walls by CLRs leads to activation of the tyrosine kinase Syk, followed by activation of PKCdelta. PKCdelta phosphorylates CARD9, enabling the assembly of a complex containing CARD9 and Bcl10. This complex activates NF-kappaB, resulting in upregulation of inflammatory cytokines important for initiation of adaptive immunity. CARD9 was also shown to be important for the induction of IL-1beta, downstream of the viral nucleic acid sensor RIG-I, as well as for the generation of reactive oxygen species important for bacterial killing by macrophages.
