Recombinant Human Interleukin-1 receptor antagonist (rHu IL-1ra)
Artikelnummer:
BWT-PR1051
Hersteller Artikelnummer:
PR1051
Alternativnummer:
BWT-PR1051-20UG,BWT-PR1051-100UG,BWT-PR1051-1.0MG
Hersteller:
Bioworld Technology
Kategorie:
Proteine/Peptide
Interleukin-1 receptor antagonist (IL-1ra) is a member of the IL-1 family. Endogenous IL-1ra is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL1-ra.The regulated expression of IL1ra in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts the synthesis of IL-1ra is markedly enhanced by IL-1 , TNF-alpha , or PDGF.
Molekulargewicht:
Approximately 17.0 kDa, a single non-glycosylated polypeptide chain containing 153 amino acids.
Quelle:
Escherichia coli
Reinheit:
>95% by SDS-PAGE and HPLC analyses.
Formulierung:
Sterile Filtered White lyophilized (freeze-dried) powder.
Lyophilized from a 0.2m filtered concentrated solution in PBS, pH 7.4.
Anwendungsbeschreibung:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20C. Further dilutions should be made in appropriate buffered solutions.
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