Recombinant Human Osteoprotegerin/Fc Chimera (rHuOPG-Fc)
Artikelnummer:
BWT-PR1106
Hersteller Artikelnummer:
PR1106
Alternativnummer:
BWT-PR1106-10UG,BWT-PR1106-50UG,BWT-PR1106-1.0MG
Hersteller:
Bioworld Technology
Kategorie:
Proteine/Peptide
Osteoprotegerin (OPG) is a member of the TNFR superfamily that can act as a decoy receptor for RANKL. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. OPG is expressed in a wide variety of tissues including adult heart, lung, kidney, liver, spleen, prostate, lymph node and bone marrow. OPG is secreted both as a monomeric and a dimeric protein. Its primary structure consists of seven distinct domains, four of which corresponds to the extracellular cysteine-rich domains of TNFR proteins and constitutes the soluble OPG.
Molekulargewicht:
Recombinant OPG/Fc contains 412 amino acid residues, including 180 residues from mature OPG (a.a 22-201) and 232 residues from the Fc protein of human IgG1, and has a calculated molecular mass of 46.5 kDa. As a result of glycosylation, the recombinant OPG
Quelle:
Pichia. Pastoris.
Reinheit:
>90% by SDS-PAGE and HPLC analyses.
Formulierung:
Sterile Filtered White lyophilized (freeze-dried) powder.
Lyophilized from a 0.2m filtered concentrated solution in PBS, pH 7.4.
Anwendungsbeschreibung:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20C. Further dilutions should be made in appropriate buffered solutions.
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