Eotaxin also called CCL11 is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-gamma stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and along Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung, and in allergic reactions.
Molekulargewicht:
Approximately 8.3 kDa, a single non-glycosylated polypeptide chain containing 74 amino acids.
Quelle:
Escherichia coli.
Reinheit:
>95% by SDS-PAGE and HPLC analyses.
Formulierung:
Sterile Filtered White lyophilized (freeze-dried) powder.
Lyophilized from a 0.2m filtered concentrated solution in PBS, pH 7.4.
Anwendungsbeschreibung:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20C. Further dilutions should be made in appropriate buffered solutions.
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