Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.Hemichannel inhibition is due to the binding of Gap19 to the C-terminus (CT) thereby preventing intramolecular CT-CL interactions. The peptide inhibited Cx43 hemichannel unitary currents in both HeLa cells exogenously expressing Cx43 and acutely isolated pig ventricular cardiomyocytes.
Molekulargewicht:
1161.4
Reinheit:
>98% (HPLC)
CAS Nummer:
[1507930-57-5]
Formel:
C55H96N14O13
Target-Kategorie:
Cx43
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