Inhibitor, inhibit, cRET, Blu667, BLU-667, BLU 667, Pralsetinib, RET
Pralsetinib (BLU-667) is a potent and selective RET kinase inhibitor effective against wild-type RET, multiple mutants (V804L, V804M, M918T), and the CCDC6-RET fusion. It is a valuable research tool for investigating RET-driven pathologies, with demonstrated activity in both cellular assays and in vivo models of RET-altered cancers.