CWHM-12 is a highly potent small molecule inhibitor targeting alphaV integrins, with sub-nanomolar IC50 values against alphavbeta8, alphavbeta3, alphavbeta6, and alphavbeta1. This compound is a valuable research tool for studying integrin-mediated pathways in fibrosis, cancer, and angiogenesis, applicable in both in vitro and in vivo experimental models.