Sirtuin, SIRT1, Selisistat S enantiomer, Selisistat Senantiomer, Selisistat S-enantiomer, inhibit, Inhibitor, EX-527, EX-527 (S-enantiomer), EX-527 S-enantiomer, EX 527, EX527, (S)-Selisistat
The S-enantiomer of Selisistat (EX-527) is a potent and selective SIRT1 inhibitor with an IC50 of 98 nM, exhibiting over 200-fold selectivity against SIRT2 and SIRT3. This compound is a valuable research tool for investigating SIRT1s role in aging, neurodegenerative diseases, and metabolic disorders in both cellular and animal models.