CVT-12012 is a potent and orally bioavailable small molecule inhibitor of stearoyl-CoA desaturase (SCD), demonstrating an IC50 of 6.1 nM in HepG2 cells. This inhibitor is a valuable research tool for investigating lipid metabolism in models of metabolic disease, cancer, and non-alcoholic fatty liver disease (NAFLD) in both in vitro and in vivo studies.