SJ6986 is a potent, selective, and orally bioavailable molecular glue degrader of GSPT1/2, achieving maximal degradation (Dmax 99%) with a DC50 of 2.1 nM. This compound is a valuable chemical probe for investigating targeted protein degradation mechanisms in oncology research, supporting both in vitro and in vivo studies of cancers dependent on GSPT1/2 function.