ATN-224 (Bis(choline)tetrathiomolybdate) is an orally bioavailable, potent inhibitor of Cu/Zn-superoxide dismutase 1 (SOD1). It exhibits dose-dependent inhibition of SOD1 activity in endothelial cells with an IC50 of 17.53.7 nM. This small molecule is utilized in research exploring oxidative stress mechanisms, angiogenesis, and in models of cancer and neurodegenerative diseases.