GNE-274 is a structurally related, non-degrading analog of GDC-0927 that functions as a potent ERalpha LBD inhibitor and partial agonist. Unlike degraders, it increases chromatin accessibility at ER binding sites without inducing receptor turnover, making it a valuable tool for studying ER-driven transcription and resistance mechanisms in breast cancer cell models.
Molekulargewicht:
457.57
CAS Nummer:
[2369048-69-9]
Formel:
C29H31NO4
Target-Kategorie:
Others,Estrogen Receptor/ERR
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