NG 25 is a potent type II kinase inhibitor targeting MAP4K2, TAK1, Src/LYN, and Abl family kinases. It demonstrates anti-inflammatory effects by inhibiting TNF-alpha-induced NF-kappaB signaling and suppresses viability in KRAS-mutant colorectal cancer cells. In vivo, it reduces tumor growth in a CT26 mouse model.
Target-Kategorie:
Kras,Others,Ras
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