This compound is a potent, selective, and competitive nonpeptide antagonist of the neuropeptide Y Y2 receptor (IC50 = 15 nM), exhibiting over 650-fold selectivity against Y1, Y4, and Y5 subtypes. Its in vivo activity makes it a valuable tool for investigating NPY Y2 receptor function in appetite regulation, anxiety, and metabolic disorders in both cellular and animal models.
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