PKF050-638 is a potent and selective small molecule inhibitor of HIV-1 Rev function, exhibiting an IC50 of 0.04 µM. It acts by disrupting the CRM1-NES interaction, thereby blocking the CRM1-mediated nuclear export of Rev. This compound is a valuable research tool for studying HIV-1 replication and nucleocytoplasmic transport mechanisms in vitro.
Molekulargewicht:
292.72
CAS Nummer:
[528893-52-9]
Formel:
C13H13ClN4O2
Target-Kategorie:
HIV Protease,CRM1
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