GSK2945 hydrochloride is a potent and selective antagonist of Rev-erbalpha/REV-ERBalpha, demonstrating EC50 values of 21.5 µM and 20.8 µM for the mouse and human isoforms, respectively. This compound is a valuable research tool for studying circadian metabolism, as it upregulates CYP7A1 to promote cholesterol catabolism in both cellular and animal models.
Molekulargewicht:
457.8
Formel:
C20H19Cl3N2O2S
Target-Kategorie:
Others
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