T1001 is a small molecule antagonist targeting HIF-2alpha. It functions by binding to the PAS-B domain, displacing residue M252 and disrupting the HIF-2alpha/ARNT heterodimerization. This inhibitor is a valuable tool for studying hypoxia signaling pathways in cancer and renal physiology through in vitro and in vivo models.
Molekulargewicht:
283.19
CAS Nummer:
[56943-06-7]
Formel:
C11H11BrN2S
Target-Kategorie:
Others
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