Ssm Spooky Toxin, derived from Scolopendra mutilans, exhibits potent lethality affecting both hematological and respiratory systems primarily through the inhibition of KCNQ (voltage-gated potassium channel family 7) channels. It demonstrates IC50 values of 2.8 µM for Kv7.4, 5.26 µM for Kv1.3, and 0.1-0.3 M for the Shal channel, respectively. Additionally, this toxin impedes cytokine production by selectively targeting the KV1.3 channel in T cells and is crucial for the centipedes circulatory system functions.
Molekulargewicht:
6017.84
Formel:
C270H413N69O79S4
Target-Kategorie:
Potassium Channel
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