PROTAC TG2 Degrader-1 (Compound 11) is a VHL-based PROTAC that targets tissue transglutaminase (TG2) and exhibits a binding affinity with a K D of 68.9 µM. This compound effectively decreases TG2 levels in ovarian cancer cells through a proteasome-dependent pathway.
Molekulargewicht:
1052.29
Formel:
C55H73N9O10S
Target-Kategorie:
PROTACs
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