FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively. It demonstrates significant antiproliferative effects on several AML cell lines, with IC50 values of 0.16 µM for EOL-1, 0.12 µM for MV-4-11, 1.05 µM for KG-1, and 1.39 µM for MOLM-16. Additionally, FD1024 has shown antitumor efficacy in murine models.
Molekulargewicht:
430.47
CAS Nummer:
[1422456-47-0]
Formel:
C21H20F2N4O2S
Target-Kategorie:
Pim
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