Tyrosinase-IN-13 (compound 3c), derived from Flurbiprofen, serves as a potent non-competitive inhibitor of tyrosinase with IC50 and Ki values of 68 µM and 36.3 µM, respectively. It exhibits cytotoxicity against several cancer cell lines, including hepatocellular carcinoma (HepG2), colorectal cancer (HT-29), and melanoma (B16F10).
Molekulargewicht:
452.93
Formel:
C23H18ClFN4OS
Target-Kategorie:
Tyrosinase
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