Antifungal agent 72 (Compound B8) demonstrates potent activity by inhibiting the efflux pump function and downregulating resistance-associated genes via disruption of the Pdr1-KIX interaction (K i : 11.7 µM). It exhibits efficacy against Fluconazole-resistant strains, evidenced by a MIC of 63 ng/mL, and displays synergistic effects when combined with Fluconazole. This compound is particularly useful for researching C. glabrata infections.
Molekulargewicht:
274.34
Formel:
C13H14N4OS
Target-Kategorie:
Others
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
