SIAIS164018 hydrochloride is a potent PROTAC degrader of ALK and EGFR, with IC50 values of 2.5 nM for ALK and 6.6 nM for the ALK G1202R mutant. It demonstrates robust anti-cancer activity in vitro by inhibiting cell migration and invasion, inducing G1 phase arrest, and promoting apoptosis, outperforming brigatinib in these assays.
Molekulargewicht:
919.79
Formel:
C43H49Cl2N10O7P
Target-Kategorie:
EGFR,Apoptosis,PROTACs,ALK
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
