Desthiobiotin-Iodoacetamide is a chemical probe designed for labeling reactive cysteine residues in proteins. It is used in proteomics for studying cysteine reactivity and protein function in vitro, and its desthiobiotin tag enables gentle streptavidin-based purification. This reagent also has potential applications as a cleavable linker in antibody-drug conjugate (ADC) research.