(S)-3-hydroxy Blebbistatin, CAS [[2097136-42-8]] Preis auf Anfrage

Produktübersicht

• Artikelname: (S)-3-hydroxy Blebbistatin, CAS [[2097136-42-8]] Preis auf Anfrage
• Artikelnummer: BYT-ORB2283104
• Hersteller Artikelnummer: orb2283104
• Alternativnummer: BYT-ORB2283104-50,BYT-ORB2283104-10
• Hersteller: Biorbyt
• Kategorie: Biochemikalien

Produktbeschreibung

(S)-3-hydroxy-Blebbistatin is a more stable and less phototoxic derivative of (-)-blebbistatin, retaining the latters properties as a selective, cell-permeable inhibitor of non-muscle myosin II ATPases. Unlike its predecessor, (S)-3-hydroxy-Blebbistatin exhibits reduced fluorescence, improving its utility in live cell imaging applications by diminishing degradation into cytotoxic intermediates under blue light exposure (450-490 nm). It effectively inhibits the Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB across various species with IC50 values ranging from 0.5-5 µM and shows minimal inhibition against smooth muscle myosin with an IC50 of 80 µM. This compound plays a critical role in preventing apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells, mirroring the active (-)-blebbistatin enantiomer in mechanism and efficacy.

Produkteigenschaften

• Molekulargewicht: 308.33
• CAS Nummer: [2097136-42-8]
• Formel: C18H16N2O3
• Target-Kategorie: Others