FAK-IN-22 (Compound 26) is a potent multi-kinase inhibitor targeting FAK, JAK3, and Aurora B (IC50s: 50.94, 9.99, and 0.49 nM, respectively). It suppresses pancreatic cancer (PDAC) proliferation, metastasis, and tumorigenesis in vitro and in vivo by inducing apoptosis and G2/M arrest via FAK/PI3K/Akt pathway inhibition.
Molekulargewicht:
427.38
CAS Nummer:
[2703920-02-7]
Formel:
C21H16F3N5O2
Target-Kategorie:
JAK,Apoptosis,FAK,Aurora Kinase,Akt,PI3K
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten