AKT-IN-25 (Compound 14a) is a potent Akt inhibitor that blocks its phosphorylation, disrupting the PI3K/Akt/mTOR pathway. It induces G1 phase cell cycle arrest, inhibits migration, and suppresses proliferation in pancreatic cancer cell lines PANC-1, PATU-T, and SUIT-2, with IC50 values ranging from 1.32 to 3.85 µM. This inhibitor is a valuable tool for studying oncogenic signaling in vitro.
Molekulargewicht:
256.3
CAS Nummer:
[1619929-59-7]
Formel:
C14H16N4O
Target-Kategorie:
Akt
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