EGFR/BRAFV600E-IN-5 (Compound 7I) is a dual inhibitor targeting both BRAFV600E and EGFR, with IC50 values of 0.048 µM and 0.037 µM, respectively. It exhibits potent anti-melanoma activity, showing IC50 values of 3.16 µM for MALME-3M cells and 2.50 µM for LOX-IMVI cells. The compound exerts its antitumor effects by inducing G1 phase arrest, inhibiting DNA synthesis, and activating the mitochondrial apoptosis pathway. EGFR/BRAFV600E-IN-5 is useful for melanoma research, especially in studies focusing on the combined inhibition of the BRAFV600E mutation and EGFR signaling pathways.
Formel:
C30H24ClN7O2S2
Target-Kategorie:
Apoptosis,Raf,EGFR,Bcl-2 Family
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