Nitric oxide production-IN-2, CAS [[1019984-44-1]] Preis auf Anfrage

Produktübersicht

• Artikelname: Nitric oxide production-IN-2, CAS [[1019984-44-1]] Preis auf Anfrage
• Artikelnummer: BYT-ORB3028918
• Hersteller Artikelnummer: orb3028918
• Alternativnummer: BYT-ORB3028918-10, BYT-ORB3028918-50
• Hersteller: Biorbyt
• Kategorie: Biochemikalien

Produktbeschreibung

TLR4/JNK/NF-kappaB-IN-1 (Racemic-11k) is an inhibitor of TLR4, JNK, and NF-kappaB. It suppresses NO production in LPS-stimulated RAW264.7 cells with an IC50 of 23.2 µM. By inhibiting TLR4 expression and reducing JNK phosphorylation, TLR4/JNK/NF-kappaB-IN-1 prevents NF-kappaB activation. This leads to a decrease in the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and the production of inflammatory mediators such as NO, PGE2, and TNF-alpha, thereby exhibiting anti-inflammatory activity. TLR4/JNK/NF-kappaB-IN-1 holds potential in the study of inflammatory diseases, including rheumatoid arthritis and various other inflammatory conditions.

Produkteigenschaften

• Molekulargewicht: 344.403
• CAS Nummer: [1019984-44-1]
• Formel: C23H20O3
• Target-Kategorie: JNK,NF-kappaB,TLR