Mavoglurant (AFQ056) is a potent, selective, non-competitive, and orally active metabotropic glutamate receptor 5 (mGluR5) antagonist with an IC50 of 30 nM, demonstrating greater than 300-fold selectivity over 238 tested targets, and it is widely applied in research on Fragile X syndrome and L-dopa-induced dyskinesias in Parkinsons disease, while Mavoglurant incorporated alkyne functional group, which enables copper-catalyzed azide-alkyne cycloaddition click chemistry, facilitating target engagement and molecular tracking studies.
Molekulargewicht:
313.39
CAS Nummer:
[543906-09-8]
Formel:
C19H23NO3
Target-Kategorie:
Cholecystokinin Receptor
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