PLK1/BRD4-IN-5 (Compound SC10) is an orally active inhibitor of PLK1 and BRD4, exhibiting IC50 values of 0.3 nM and 60.8 nM, respectively. It induces S phase cell cycle arrest and dose-dependent apoptosis in MV4-11 cells. PLK1/BRD4-IN-5 is useful for cancer research.
Formel:
C31H44N8O3
Target-Kategorie:
Apoptosis,Epigenetic Reader Domain,PLK
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