NZ-97 is an inhibitor of dipeptidyl peptidase 4 (DPP4) with an IC50 of 18 nM. It exhibits low initial plasma exposure with a Cmax of 0.13 µM and is eliminated within 8 hours. NZ-97 can ameliorate lipopolysaccharides-induced lung injury and bleomycin-induced pulmonary fibrosis in mouse models.
Formel:
C43H67N5O9
Target-Kategorie:
Proteasome
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