Antibiofilm agent-6 (Compound 26c) is a quorum sensing inhibitor with antibiofilm properties, effectively reducing the fluorescence intensity of PAO1-lasB-gfp and PAO1-pqsA-gfp in a concentration-dependent manner. It suppresses the production of pyocyanin and rhamnolipids and enhances the efficacy of ciprofloxacin in eradicating viable bacteria in a Pseudomonas aeruginosa (P. aeruginosa PAO1) infected mouse model.
Formel:
C15H12FN3O3
Target-Kategorie:
Antibacterial
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